Brain Tumors & The Usage Of A Two-Drug Tandem

By Robbie Sutter


Brain tumors can be helped with the implementation of certain drugs but what does this entail, one has to wonder? It's apparent that there are drugs which have been utilized to help separate conditions in the past but I'd like to think that there are those which are entirely unique. Whatever the case may be, there is potential to consider with the results that they can bring to the surface. Is it possible that further results can come about because of a particular two-drug tandem?

YottaFire posted an article that spoke about a combination of drugs that could come into play in order to help stop the rate at which brain tumors progress. A study that was done featured a group of mice that was afflicted with the condition. With the usage of the drug tandem, it was found that their survival rates were made much better. This is reason enough why the study is worthy of the attention of organizations like Voices against Brain Cancer but what are the specifics behind it?

Dana-Farber Cancer Institute put together the study and it was determined that a combination of two drugs working together could play positively into the actions of glioblastoma. With this particular tandem, it would be able to focus on two cell signaling pathways. A previous study was done but it was deemed unsuccessful because of how only one pathway was focused on. While this improvement is worthy of note, what is more worthy has got to be a certain abnormality that is typical amongst one-third of glioblastoma patients.

These patients, from what I have gathered, seem to lack a certain gene by the name of PTEN. This may not be a common name to most but be certain that this gene works as something of a tumor-suppressant. If PTEN is not seen in the body, an excessive amount of molecular growth can occur, which means that the malignant rate of said growth can reach the brain as well. It is uncertain if PTEN can be replaced but the drug combination spoken about before can halt the level of growth seen.

It's apparent that the human body goes about all types of actions, whether or not we know of them. It's clear that we won't be able to understand all of them but it is clear that they are carried out for certain reasons. For example, the lack of PTEN is one that can bring brain tumors to the surface. It's an unfortunate case to make but the truth of the matter is that there are certain drugs that can be utilized; it's just a matter of determining how effective they will be from one patient to the next.




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